Key findings from detailed records
Population: 40 Asian men and women aged 35–64 Findings: Improvements versus placebo were reported across several skin measures.
KNOWLEDGE RECORD
- Category
- Skin and connective tissue
- Last Reviewed
Names and related search termsHyaluronic acid / Hyaluronic acid / Hyaluronan / HA
Study type: human intervention study.
OUTCOME-SPECIFIC EVIDENCE
Scientific Evidence Profile
Assessment pending
An outcome-specific assessment has not yet been completed. This is not a finding that the ingredient is ineffective. The study records below remain available.
This profile concerns the stated outcome and population, not the ingredient as a whole. It is not a probability of benefit, a safety rating, a product efficacy rating or an indication of product adoption.
How we assess evidenceIngredient Profile
- What material is being studied?
- This page concerns oral hyaluronan. A preparation swallowed in a trial is a different intervention from an injection or a skin-care product; route and molecular weight belong in the comparison. [1]
Sources for this profile
Compound properties and formulation properties are different. These sources do not establish the efficacy of a finished supplement.
- Oral Hyaluronan Relieves Wrinkles and Improves Dry Skin: A 12-Week Double-Blinded, Placebo-Controlled Study. Identity and preparation checked against the study abstract. Funded by Kewpie Corporation. Oe, Matsuoka and Masuda were Kewpie employees; other authors reported no other conflicts.
Profile sources checked:
Read the evidence in context
- Evidence: what was measured in the stated population or experimental model.
- Inference: an interpretation connecting findings; its applicability depends on the study conditions.
- Hypothesis: a proposed explanation or effect that remains to be tested.
Why It Matters #
How far have skin outcomes from oral intake been established? Check the detailed records for study conditions and use the literature map to compare other populations and outcomes.
What Was Studied #
Forty Asian adults aged 35–64 took part in a randomized, double-blind, placebo-controlled trial assessing wrinkles, skin hydration, barrier function and elasticity.[1]
What Was Found #
Improvements versus placebo were reported across several skin measures.[1]
What the Evidence Means #
Small sample, short duration and multiple measures. It does not establish effects on joint symptoms, lifespan or all molecular weights and formulations.[1]
Comparing similar populations, formulations, durations and outcomes helps identify where findings agree and where they differ.
What We Can Learn #
Distinguish skin measurements from whole-body aging, and injectable products from evidence on oral intake.
What Remains Unknown #
Further questions include reproducibility across populations and formulations, and the long-term balance of benefits and harms. Use the literature map as a starting point for these questions.
LITERATURE MAP / 10 PAPERS
Compare papers by conditions and findings.
A literature map covering different populations, outcomes and formulations. Read alongside detailed records to avoid treating one trial as the conclusion for an entire ingredient.
Selected: 2026-09-21. Bibliographic information checked against Europe PMC / PubMed. Editorial selection considered major papers and a range of populations and questions. This is not a systematic search covering all recent research.
10 RECORDS
A dash marks fields outside the bibliographic record. Use detailed records to compare findings and design records to connect mechanisms.
No papers match. Change the search conditions.
The literature map is an index of research questions and references. Individual assessment of results, doses, funding and COI is limited to the detailed study records. Related reports from the same trial may be included; paper counts are not counts of independent trials.
Explore the research Study Records
Listed doses describe study conditions, not recommended intake.
Oral Hyaluronan Relieves Wrinkles and Improves Dry Skin: A 12-Week Double-Blinded, Placebo-Controlled Study.
PubMed 34203487DOI: 10.3390/nu13072220
- Authors
- Hsu TF, Su ZR, Hsieh YH, Wang MF, Oe M, Matsuoka R, Masuda Y.
- Journal
- Nutrients
- Publication year
- 2021
- Study design
- Randomized, double-blind, placebo-controlled trial
- Participants
- 40 Asian men and women aged 35–64
- Dose and intervention
- Hyaluronic acid 120 mg/day
- Duration
- 12 weeks
- Outcomes and their role in the study
- Skin outcomes included wrinkles, stratum corneum hydration, transepidermal water loss and elasticity.
- Findings
- Improvements versus placebo were reported across several skin measures.
- Limitations
- Small sample, 12-week duration and multiple measures. No adverse events attributable to hyaluronan were reported. These findings do not establish long-term safety or effects of other formulations.
- Funding
- Funded by Kewpie.
- Conflict of Interest
- Three authors were Kewpie employees. Other authors declared no other conflicts related to this study.
- Scope of source review
- Primary full text checked for participants, intervention, results, limitations, funding and conflicts of interest on 2026-10-24.
Cite this page
LÍFSVARÐA. Hyaluronic acid: How far have skin outcomes from oral intake been established? Version 1.1 / Updated 2026-10-24
https://lifsvarda.com/knowledge/hyaluronic-acid/Edited by LÍFSVARÐA (product brand).Editorial policy
Sources and updates
- Hsu TF, Su ZR, Hsieh YH, Wang MF, Oe M, Matsuoka R, Masuda Y. (2021). Oral Hyaluronan Relieves Wrinkles and Improves Dry Skin: A 12-Week Double-Blinded, Placebo-Controlled Study.Primary full text checked for participants, intervention, results, limitations, funding and conflicts of interest on 2026-10-24.
First published: 2026-09-21 / Version 1.1. Updated 2026-09-23: Added a research comparison table and links to design records. Source notes identify the scope of verification when the full paper has not been reviewed. Research summaries and LÍFSVARÐA’s interpretation are distinguished.