Key findings from detailed records
Short trials suggest blood-pressure or weight changes with some preparations. A six-month trial of isolated chlorogenic acid in diabetes with fatty liver did not improve the main liver outcomes.
KNOWLEDGE RECORD
- Category
- Metabolism and cellular function
- Last Reviewed
- 2026-09-27
Names and related search termsCGA; chlorogenic acids; caffeoylquinic acids; green coffee extract
OUTCOME-SPECIFIC EVIDENCE
Scientific Evidence Profile
Assessment pending
An outcome-specific assessment has not yet been completed. This is not a finding that the ingredient is ineffective. The study records below remain available.
This profile concerns the stated outcome and population, not the ingredient as a whole. It is not a probability of benefit, a safety rating, a product efficacy rating or an indication of product adoption.
How we assess evidenceIngredient Profile
- What is it?
- Chlorogenic acid is an ester of caffeic acid and quinic acid. It is a plant compound, distinct from caffeine even when both are discussed in relation to coffee. [1]
Sources for this profile
Compound properties and formulation properties are different. These sources do not establish the efficacy of a finished supplement.
- PubChem — Chlorogenic Acid (CID 1794427) Chemical identity reference. Maintained by NCBI, U.S. National Library of Medicine. Database record; not a clinical trial.
Profile sources checked:
Read the evidence in context
- Evidence: what was measured in the stated population or experimental model.
- Inference: an interpretation connecting findings; its applicability depends on the study conditions.
- Hypothesis: a proposed explanation or effect that remains to be tested.
Why It Matters #
Chlorogenic acids are a family of plant phenolic compounds found in coffee and other foods. Coffee also contains caffeine and many other substances. An association between coffee drinking and health cannot identify chlorogenic acid as its cause. Isolated compound, green-coffee extract and the brewed beverage require separate evaluation.
What Was Studied #
Human studies include acute blood-pressure experiments, short trials of chlorogenic-acid-rich extracts and longer trials of isolated chlorogenic acid. Absorption studies also show extensive metabolism: the compounds and metabolites reaching circulation differ from those initially swallowed, with an important contribution from the colon.[2][4][3][11]
What Was Found #
A five-trial meta-analysis estimated lower blood pressure, but heterogeneity was high and the trials were predominantly Asian and manufacturer-funded. A single-dose crossover trial in 23 healthy adults found small blood-pressure differences after 400 mg, without a corresponding change in the measured nitric-oxide/endothelial markers.[1][2]
A short-term green-coffee-extract synthesis estimated 1.30 kg greater weight reduction across only three trials and 103 participants. In contrast, 200 mg/day isolated chlorogenic acid, with or without caffeine, did not improve hepatic fat or stiffness over six months in people with type 2 diabetes and fatty liver.[4][3]
What the Evidence Means #
The evidence does not support treating “coffee is associated with health” and “chlorogenic acid supplements improve health” as equivalent statements. The weight estimate applies to selected extracts, not pure chlorogenic acid or an extra cup of coffee. Acute blood-pressure changes also need sustained replication.
What We Can Learn #
Record the amount of chlorogenic acids, total extract mass and caffeine content separately. A preparation’s dose and matrix affect what is actually being tested. The six-month liver trial provides more duration than an acute experiment, but its findings concern that clinical population and regimen; it cannot resolve rare adverse effects or all formulations.
What Remains Unknown #
Independent longer trials of chemically defined preparations are needed to determine sustained effects on blood pressure, glucose and function. It also remains unclear which metabolites matter, how microbiome differences alter exposure and whether any coffee-associated benefit can be reproduced by isolated supplementation.
LITERATURE MAP / 10 PAPERS
Compare papers by conditions and findings.
Compare populations, preparations, doses and outcomes. Detailed records below assess selected studies; the remaining entries provide a bibliographic route into related questions.
Selected: 2026-09-27. Bibliographic information checked against Europe PMC / PubMed. This editorial selection includes major trials, evidence syntheses and different research questions; it is not an exhaustive systematic review. Paper counts are not counts of independent trials.
10 RECORDS
A dash marks fields not assessed in a bibliographic-only record.
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Explore the research Study Records
Listed doses describe study conditions, not recommended intake.
The effect of chlorogenic acid on blood pressure: a systematic review and meta-analysis of randomized clinical trials.
PubMed 24943289 DOI: 10.1038/jhh.2014.46
- Authors
- Onakpoya IJ, Spencer EA, Thompson MJ, Heneghan CJ.
- Journal
- Journal of human hypertension
- Publication year
- 2015
- Study design
- Systematic review and meta-analysis of randomized trials
- Participants
- Five trials; 364 participants
- Dose and intervention
- Chlorogenic-acid interventions versus control; preparations varied
- Duration
- Durations varied
- Outcomes and their role in the study
- Systolic and diastolic blood pressure
- Findings
- Systolic difference −4.31 mmHg (95% CI −5.60 to −3.01); diastolic −3.68 mmHg (−3.91 to −3.45).
- Limitations
- High heterogeneity (65% systolic, 97% diastolic); included trials were Asian and manufacturer-funded.
- Funding
- Not verified in the source material available for this record.
- Conflict of Interest
- Not verified in the source material available for this record.
- What We Can Learn
- A pooled signal is not a precise prediction for a different population or preparation.
- Scope of source review
- Original abstract and bibliographic record reviewed; unavailable full-text details are not inferred.
Acute effects of chlorogenic acid on nitric oxide status, endothelial function, and blood pressure in healthy volunteers: a randomized trial.
PubMed 22900702 DOI: 10.1021/jf303440j
- Authors
- Mubarak A, Bondonno CP, Liu AH, Considine MJ, Rich L, Mas E, Croft KD, Hodgson JM.
- Journal
- Journal of agricultural and food chemistry
- Publication year
- 2012
- Study design
- Randomized, placebo-controlled crossover experiment
- Participants
- 23 healthy adults
- Dose and intervention
- Single 400 mg chlorogenic acid dose versus placebo
- Duration
- Acute post-dose testing
- Outcomes and their role in the study
- Blood pressure, endothelial function and nitric-oxide-related markers
- Findings
- Systolic pressure differed by −2.41 mmHg (P=0.05) and diastolic by −1.53 mmHg (P=0.04); measured endothelial/NO outcomes were unchanged.
- Limitations
- Small acute experiment; borderline statistics and no sustained clinical outcome.
- Funding
- Not verified in the source material available for this record.
- Conflict of Interest
- Not verified in the source material available for this record.
- What We Can Learn
- A short-term pressure effect did not demonstrate the proposed mechanism or long-term benefit.
- Scope of source review
- Original abstract and bibliographic record reviewed; unavailable full-text details are not inferred.
Effects of supplementation with main coffee components including caffeine and/or chlorogenic acid on hepatic, metabolic, and inflammatory indices in patients with non-alcoholic fatty liver disease and type 2 diabetes: a randomized, double-blind, placebo-controlled, clinical trial.
PubMed 33838673 DOI: 10.1186/s12937-021-00694-5
- Authors
- Mansour A, Mohajeri-Tehrani MR, Samadi M, Qorbani M, Merat S, Adibi H, Poustchi H, Hekmatdoost A.
- Journal
- Nutrition journal
- Publication year
- 2021
- Study design
- Randomized, double-blind, four-arm placebo-controlled trial
- Participants
- Adults with type 2 diabetes and nonalcoholic fatty liver disease
- Dose and intervention
- Chlorogenic acid 200 mg/day, caffeine 200 mg/day, their combination, or placebo
- Duration
- 6 months
- Outcomes and their role in the study
- Primary liver-fat, stiffness and injury outcomes; metabolic and inflammatory markers
- Findings
- Neither chlorogenic acid nor caffeine improved the main liver outcomes over placebo. Most metabolic outcomes were also unchanged.
- Limitations
- Specific disease population and dose; no inference about all coffee constituents or higher-dose extracts.
- Funding
- Supported by Iranian medical research and nutrition research institutes, as detailed in the original Funding section.
- Conflict of Interest
- The authors declared no conflicts of interest or financial ties.
- What We Can Learn
- An observational coffee association did not translate into the expected isolated-component liver effect.
- Scope of source review
- Original full text and bibliographic record reviewed.
Cite this page
LÍFSVARÐA. Chlorogenic Acid: Can coffee findings be attributed to one compound? Version 1.0 / Updated 2026-10-24
https://lifsvarda.com/knowledge/chlorogenic-acid/Edited by LÍFSVARÐA (product brand). Editorial policy
Primary Sources and updates
- Onakpoya IJ, Spencer EA, Thompson MJ, Heneghan CJ. (2015). The effect of chlorogenic acid on blood pressure: a systematic review and meta-analysis of randomized clinical trials. Journal of human hypertension DOI: 10.1038/jhh.2014.46Original abstract and bibliographic record reviewed; unavailable full-text details are not inferred.
- Mubarak A, Bondonno CP, Liu AH, Considine MJ, Rich L, Mas E, Croft KD, Hodgson JM. (2012). Acute effects of chlorogenic acid on nitric oxide status, endothelial function, and blood pressure in healthy volunteers: a randomized trial. Journal of agricultural and food chemistry DOI: 10.1021/jf303440jOriginal abstract and bibliographic record reviewed; unavailable full-text details are not inferred.
- Mansour A, Mohajeri-Tehrani MR, Samadi M, Qorbani M, Merat S, Adibi H, Poustchi H, Hekmatdoost A. (2021). Effects of supplementation with main coffee components including caffeine and/or chlorogenic acid on hepatic, metabolic, and inflammatory indices in patients with non-alcoholic fatty liver disease and type 2 diabetes: a randomized, double-blind, placebo-controlled, clinical trial. Nutrition journal DOI: 10.1186/s12937-021-00694-5Original full text and bibliographic record reviewed.
- Kanchanasurakit S, Saokaew S, Phisalprapa P, Duangjai A. (2023). Chlorogenic acid in green bean coffee on body weight: a systematic review and meta-analysis of randomized controlled trials. Systematic reviews DOI: 10.1186/s13643-023-02311-4Bibliographic record; not a detailed study appraisal.
- Asbaghi O, Sadeghian M, Nasiri M, Khodadost M, Shokri A, Panahande B, Pirouzi A, Sadeghi O. (2020). The effects of green coffee extract supplementation on glycemic indices and lipid profile in adults: a systematic review and dose-response meta-analysis of clinical trials. Nutrition journal DOI: 10.1186/s12937-020-00587-zBibliographic record; not a detailed study appraisal.
- Asbaghi O, Sadeghian M, Rahmani S, Mardani M, Khodadost M, Maleki V, Pirouzi A, Talebi S, Sadeghi O. (2020). The effect of green coffee extract supplementation on anthropometric measures in adults: A comprehensive systematic review and dose-response meta-analysis of randomized clinical trials. Complementary therapies in medicine DOI: 10.1016/j.ctim.2020.102424Bibliographic record; not a detailed study appraisal.
- Suzukamo C, Ochiai R, Mitsui Y, Osaki N, Ono T. (2022). Short-Term Intake of Chlorogenic Acids Improves Psychomotor Speed and Motor Speed in Adults: A Randomized Crossover Trial. Brain sciences DOI: 10.3390/brainsci12030370Bibliographic record; not a detailed study appraisal.
- Faraji H. (2018). Effect of Decaffeinated Coffee-enriched Chlorogenic Acid on Blood Glucose Levels in Healthy Controls: A Systematic Review. International journal of preventive medicine DOI: 10.4103/ijpvm.ijpvm_343_17Bibliographic record; not a detailed study appraisal.
- Terzo S, Amato A, Magán-Fernández A, Castellino G, Calvi P, Chianetta R, Giglio RV, Patti AM, Nikolic D, Firenze A, Mulè F, Ciaccio M, Rizzo M. (2023). A Nutraceutical Containing Chlorogenic Acid and Luteolin Improves Cardiometabolic Parameters in Subjects with Pre-Obesity: A 6-Month Randomized, Double-Blind, Placebo-Controlled Study. Nutrients DOI: 10.3390/nu15020462Bibliographic record; not a detailed study appraisal.
- Johal K, Jones DJW, Bell L, Lovegrove JA, Lamport DJ. (2025). Impact of coffee-derived chlorogenic acid on cognition: a systematic review and meta-analysis. Nutrition research reviews DOI: 10.1017/s0954422424000209Bibliographic record; not a detailed study appraisal.
- Stalmach et al. Bioavailability of chlorogenic acids following acute ingestion of coffee by humans with an ileostomy (2010).
First published: 2026-09-27 / Version 1.0. Sources reviewed 2026-09-27. Funding and conflicts are recorded separately; an unverified disclosure is not a declaration of no funding or no conflict.